Alcohol dehydrogenase 3 genotype is not predictive for risk of colorectal cancer.
نویسندگان
چکیده
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York [J. C.]; Channing Laboratory [J. M., M. J. S., L. M. H., D. J. H.], Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Departments of Epidemiology [M. J. S., L. M. H., D. J. H.] and Nutrition [M. J. S.], Harvard School of Public Health, Boston, Massachusetts; Jean Mayer USDA Human Nutrition Center on Aging at Tufts University, Boston, Massachusetts [J. S.]
منابع مشابه
Association between alcohol, dietary factors and subsites of colorectal cancer: an ecological study
Background: Colorectal cancer is the fourth most common cancer, in terms of incidence throughout the world. There are some differences for risk factors involved in the incidence of tumor in different anatomical subsites of large bowel. However, most investigations have not studied the association between dietary factors and colorectal cancer subsites. Thus the current ecological study inves...
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Alcohol is a probable risk factor with regard to colorectal neoplasm and is metabolized to the carcinogen acetaldehyde by the genetically polymorphic alcohol dehydrogenase 3 (ADH3) enzyme. We evaluated whether the association between alcohol and colorectal adenomas is modified by ADH3 polymorphism. We recruited 433 cases with adenomatous polyps and 436 polyp-free controls among Caucasians under...
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متن کاملGenetic polymorphism of enzymes involved in xenobiotic metabolism and the risk of colorectal cancer.
Environmental factors such as smoking cigarette, diets and alcohol may interact with genetic factors, which put one individual at a greater or lesser risk of a particular cancer than another. Advances in molecular biology have allowed many allelic variants of several drug metabolizing enzymes so that individuals with the susceptible genotypes can be determined easily. Many pieces of research ha...
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Introduction & Objective: One candidate gene for colorectal cancer susceptibility is exonuclease1 (EXO1) .It is a member of RAD2 nuclease family. It plays a main role in mismatch repair. EXO1 acts also in DNA replication and recombination. Single nucleotide polymorphisms (SNPs) are shown to be related with cancer incidence. The aim of the present study was to examine the association between P...
متن کاملAldehyde dehydrogenase 2 (ALDH2) genotype affects rectal cancer susceptibility due to alcohol consumption.
BACKGROUND Epidemiologic studies have shown the association between alcohol consumption and colorectal cancer, especially for rectal cancer. The alcohol related enzyme encoding gene ALDH2 has polymorphism Glu487Lys, and 487Lys allele is closely linked with phenotypic loss of enzyme activity. MATERIALS AND METHODS A hospital-based case-control study was conducted with 72 colon and 70 rectal ca...
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ورودعنوان ژورنال:
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
دوره 10 12 شماره
صفحات -
تاریخ انتشار 2001